Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma

Abstract Tumor hypoxia is an important factor for developing resistance to radiation therapy (RT) and presents a bleak prognosis in cancer patients undergoing treatment RT resistant hepatocellular carcinoma. Here, we present the synthesis of liposome-coated Mn 3 O 4 (MGN) nanoparticles (Lipo-MGN) investigation their therapeutic potential with utilizing HepG2 model. According vitro research, Lipo-MGN effectively produced oxygen presence H 2 significantly reduced expression HIF-1 human cells that were under hypoxic conditions. reversed radio-resistance brought on by increased cell damage. When administered together xenograft mice model, tumor growth was delayed more than alone. As determined MR imaging, liposome-MGN also exhibited T1 contrast enhancement tumor. these findings, Lipo-MGNs may increase impact focusing hypoxia. Hypoxic, radioresistant be treated clinical studies.